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Cynomolgus IL-13 R alpha 1 Protein, His Tag

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IL1-C52H8-100ug
¥3310.00
IL1-C52H8-1mg
¥18900.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    IL13RA1,CD213A1,IL-13Ra,NR4,RP13-128O4.2,IL13Rα1

  • 表达区间及表达系统(Source)

    Cynomolgus IL-13 R alpha 1, His Tag (IL1-C52H8) is expressed from human 293 cells (HEK293). It contains AA Ala 25 - Thr 341 (Accession # XP_005594500.1).

    Predicted N-terminus: Ala 25

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IL-13 R alpha 1 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 38.4 kDa. The protein migrates as 47-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

数据展示

  • 电泳(SDS-PAGE)

    IL-13 R alpha 1 SDS-PAGE

    Cynomolgus IL-13 R alpha 1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • 活性(Bioactivity)-BLI

     IL-13 R alpha 1 BLI

    Loaded Human IL-13, Fc Tag (Cat. No. IL3-H5256) on Protein A Biosensor, can bind Cynomolgus IL-13 R alpha 1, His Tag (Cat. No. IL1-C52H8) with an affinity constant of 0.739 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

    Protocol

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背景介绍

Interleukin 13 receptor, alpha 1 is also known as IL13RA1, NR4 and CD213A1 (cluster of differentiation 213A1), The IL13 Rα1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. Human and mouseIL13Rα1 share 76% aa sequence identity. IL13RA1 is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.

前沿进展

 
药物研发进展
  • 英文全称:

    Interleukin-13 receptor subunit alpha-1

  • 中文全称:

    白介素-13受体α1亚基

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    1 详情

  • 最高研发阶段:

    临床二期

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