STAT通路与疾病发生
热门通路
JAK/STAT5
信号通路：肺和肠道上皮细胞和角质形成细胞收到刺激后释放TSLP，与其受体TSLPR结合形成二聚体后募集IL-7Rα，形成三元TSLPR-TSLP-IL-7Rα复合物，进而通过JAK和STAT5启动促炎信号。
相关疾病：过敏性疾病、慢性炎症、自身免疫性疾病、癌症等。
热门产品：TSLP、TSLPR、IL-7 R alpha、IL-7 R alpha & TSLP R Hot、TSLP抑制剂筛选试剂盒、TSLPR报告基因细胞系New。
JAK/STAT3
信号通路：JAK激酶是许多细胞因子、生长因子及干扰素的重要信号传感器。在某些应激反应条件下，一些细胞因子与相应的受体结合，诱导JAK磷酸化，从而使STAT3活化，促使STAT3的二聚化、核易位、与特定的DNA序列结合，行使基因转录调控的功能。
相关疾病：肿瘤、免疫类疾病、感染类疾病等。
热门产品：细胞因子、生长因子、JAK1 New、STAT3New、EGFR预偶联磁珠、EGFR报告基因细胞系、STAT3报告基因细胞系。
JAK/STAT3
- 免疫/结合验证——靶点蛋白&受体
- 抗体/抑制剂筛选——预偶联磁珠
- 细胞水平功能验证——报告基因细胞系
免疫/结合验证——靶点蛋白&受体
靶点蛋白：
种属选择多样：覆盖Human、Mouse、Cynomolgus不同种属；
标签选择丰富：提供His、His & Avi、Fc、mFc、Fc & Fc不同产品形式；
纯度活性保证：纯度经SDS-PAGE、MALS验证>90%，与降解剂结合活性经BLI、SPR等实验方法验证。
| 分子 | 货号 | 物种 | 产品描述 | 订购/预购 |
|---|---|---|---|---|
| EGF | EGF-H5117 | Human | Human EGF Protein, premium grade | |
| EGF-H525b | Human | Human EGF Protein, Mouse IgG2a Fc Tag | ||
| EGF-H52H3 | Human | Human EGF Protein, His Tag | ||
| EGF-M5265 | Mouse | Mouse EGF Protein, Fc Tag | ||
| EGF R | EGR-C5252 | Rhesus macaque | Rhesus macaque EGF R Protein, Fc Tag (MALS verified) | |
| EGR-C52H1 | Rhesus macaque | Rhesus macaque EGF R Protein, His Tag (MALS verified) | ||
| EGR-H5222 | Human | Human EGF R Protein, His Tag (MALS verified) | ||
| EGR-H522a | Human | Human EGF R Protein, His Tag, low endotoxin (MALS verified) | ||
| EGR-H5252 | Human | Human EGF R Protein, Fc Tag (MALS verified) | ||
| EGR-H5259 | Human | Human EGF R Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified) | ||
| EGR-H82E3 | Human | Biotinylated Human EGF R Protein, His,Avitag™ (MALS verified) | ||
| EGR-H82F8 | Human | Biotinylated Human EGF R Protein, Fc,Avitag™ (MALS verified) | ||
| EGR-HA2H8 | Human | APC-Labeled Human EGF R Protein, His TagStar Staining | ||
| EGR-HF256 | Human | FITC-Labeled Human EGF R Protein, Fc Tag | ||
| EGR-HF2H5 | Human | FITC-Labeled Human EGF R Protein, His Tag | ||
| EGR-HP2E3 | Human | PE-Labeled Human EGF R Protein, His Tag (Site-specific conjugation) | ||
| EGR-HP2H7 | Human | PE-Labeled Human EGF R Protein, His TagStar Staining | ||
| EGR-M5224 | Mouse | Mouse EGF R Protein, His Tag (MALS verified) | ||
| EGR-M5257 | Mouse | Mouse EGF R Protein, Fc Tag (MALS verified) | ||
| EGR-M82E3 | Mouse | Biotinylated Mouse EGF R Protein, His,Avitag™ (MALS verified) | ||
| EGR-M82F3 | Mouse | Biotinylated Mouse EGF R Protein, Fc,Avitag™ (MALS verified) | ||
| EGR-R52H7 | Rabbit | Rabbit EGF R Protein, His Tag (MALS verified) | ||
| IL-6 | GMP-L06H27 | Human | GMP Human IL-6 Protein | |
| IL6-C5249 | Cynomolgus | Cynomolgus IL-6 Protein, His Tag (MALS verified) | ||
| IL6-H4218 | Human | Human IL-6 Protein, premium grade | ||
| IL6-H5243 | Human | Human IL-6 Protein, His Tag (MALS verified) | ||
| IL6-H8218 | Human | Biotinylated Human IL-6 Protein, epitope tag free, ultra sensitivity, primary amine labeling | ||
| IL6-H82Q9 | Human | Biotinylated Human IL-6 Protein, Avitag™,His Tag (MALS verified) | ||
| IL6-M5245 | Mouse | Mouse IL-6 Protein, His Tag | ||
| IL6-M82Q7 | Mouse | Biotinylated Mouse IL-6 Protein, Avitag™,His Tag | ||
| IL-6 R alpha | CD6-H82E8 | Human | Biotinylated Human IL-6 R alpha / CD126 Protein, Avitag™,His Tag (MALS verified) | |
| ILR-H4223 | Human | Human IL-6 R alpha / CD126 Protein, His Tag (MALS verified) | ||
| ILR-H5259 | Human | Human IL-6 R alpha / CD126 Protein, Fc Tag | ||
| ILR-H82F9 | Human | Biotinylated Human IL-6 R alpha / CD126 Protein, Fc,Avitag™ | ||
| ILR-M5255 | Mouse | Mouse IL-6 R alpha / CD126 Protein, Fc Tag (MALS verified) | ||
| ILR-M82E9 | Mouse | Biotinylated Mouse IL-6 R alpha / CD126 Protein, His,Avitag™ |
The purity of Human STAT3, His Tag (Cat. No. ST3-H5149) is more than 95% verified by SDS-PAG and greater than 90% verified by SEC-MALS. The molecular weight of this protein is around 60-75 kDa.
Protocol
Human STAT3, His Tag (Cat. No. ST3-H5149) immobilized on CM5 Chip can bind STAT3 degrader with an affinity constant of 44.6 nM as determined in a SPR assay (Biacore 8K) (QC tested).
Protocol
JAK/STAT5
- 免疫/结合验证——靶点蛋白&受体
- 抗体/抑制剂筛选——抑制剂筛选试剂盒
- 细胞水平功能验证——报告基因细胞系
免疫/结合验证——靶点蛋白&受体
靶点蛋白：
标签选择丰富：提供His、His & Avi、Fc、mFc、Fc & Fc不同产品形式；
模拟天然构象：除TSLP、TSLP R、IL-7 R外，特别推出行业新品TSLP R & IL7 R异源二聚体，真实模拟天然构象；
纯度及活性保证：纯度经SDS-PAGE、MALS验证，活性经ELISA、SPR、BLI等多平台验。
| 分子 | 货号 | 物种 | 产品描述 | 订购/预购 |
|---|---|---|---|---|
| TSLP | TSP-C52H4 | Cynomolgus | Cynomolgus TSLP (R127A, R130S) Protein, His Tag (HPLC verified) | |
| TSP-C52H8 | Cynomolgus | Cynomolgus TSLP Protein, His Tag | ||
| TSP-C82E3 | Cynomolgus | Biotinylated Cynomolgus TSLP Protein, His,Avitag™ | ||
| TSP-H5243 | Human | Human TSLP Protein (R127A, R130A), His Tag (MALS verified) | ||
| TSP-H5255 | Human | Human TSLP (R127A, R130A) Protein, Mouse IgG2a Fc Tag (MALS verified) | ||
| TSP-H52Ha | Human | Human TSLP (R127A, R130A) Protein, His Tag (MALS verified) | ||
| TSP-H52Hb | Human | Human TSLP Protein, His Tag, premium grade | ||
| TSP-H82E0 | Human | Biotinylated Human TSLP (R127A, R130A) Protein, His,Avitag™ (MALS verified) | ||
| TSP-H82Eb | Human | Biotinylated Human TSLP Protein, His,Avitag™ (MALS verified) | ||
| TSP-M52H8 | Mouse | Mouse TSLP Protein, His Tag (MALS verified) | ||
| TSP-M82E3 | Mouse | Biotinylated Mouse TSLP Protein, His,Avitag™ | ||
| TSP-R52H3 | Rat | Rat TSLP Protein, His Tag | ||
| TSLP R | TSR-H525a | Human | Human TSLP R Protein, Fc Tag (MALS verified) | |
| TSR-H82F3 | Human | Biotinylated Human TSLP R Protein, Fc,Avitag™ | ||
| IL-7 R alpha & TSLP R | ILR-H5255 | Human | Human IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (MALS verified) | |
| ILR-H525x | Human | Human IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag | ||
| IL-7 R alpha | IL7-H5258 | Human | Human IL-7 R alpha / CD127 Protein (I66T, V138I), Mouse IgG2a Fc Tag | |
| IL7-H52H7 | Human | Human IL-7 R alpha / CD127 Protein, His Tag | ||
| IL7-H82F9 | Human | Biotinylated Human IL-7 R alpha / CD127 Protein, Fc,Avitag™ | ||
| ILA-H525a | Human | Human IL-7 R alpha / CD127 Protein, Fc Tag | ||
| ILR-M5253 | Mouse | Mouse IL-7 R alpha / CD127 Protein, Fc Tag |
The purity of Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H5255) is greater than 95% verified by SDS-PAGE. The purity of the heterodimer is more than 85% and the molecular weight of this protein is around 125-140 kDa verified by SEC-MALS.
Protocol
Serial dilutions of Monoclonal Anti-Human TSLP Antibody, Human IgG2 were added into Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H5255): Biotinylated Human TSLP, His,Avitag (Cat. No. TSP-H82Eb) binding reactions. The half maximal inhibitory concentration (IC50) is 1.09688 μg/mL (Routinely tested).
Protocol
- 背景
- 热门通路
- JAK/STAT3
- JAK/STAT5