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resDetect™ Human 4-1BB Ligand ELISA Kit (Residue Testing)

COADSMS
DS中文
DS
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RES-A036-96tests
¥2940.00
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产品详情

  • 产品参数（Product Specifications）

    Assay Type
    Sandwich-ELISA
    Analyte
    4-1BB Ligand
    Format
    96T(8×12 strips)
    Reactivity
    Human
    Regulatory Status
    RUO
    Sensitivity
    ＜15.625pg/mL
    Standard Curve Range
    15.625 pg/mL-500 pg/mL
    Assay Time
    2 hr 50 min
    Suitable Sample Type
    For the detection and quantitative determination of 4-1BB Ligand in human serum and cell culture supernatant.
    Sample volume
    100 uL

  • 产品概述（Product Overview）

    resDetect™ Human 4-1BB Ligand ELISA Kit (Residue Testing) is based on the ELISA sandwich method and is used to detect and quantitatively determine GMP human 4-1BB Ligand residues in cell culture supernatants, serum, and plasma. The kit contains GMP human 4-1BB Ligand (ACROBiosystems, cat# GMP-41LH26) to ensure accurate assay results and is designed to provide a reliable solution for CAR-T product quality assessment during drug development and CMC quality control stages. It can also be used as a universal detection tool for the quantitative determination of Human 4-1BB Ligand.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for details of reconstitution instruction and specific concentration.

  • 存储（Storage）

    1. Unopened kit should be stored at 2℃-8℃ upon receiving.

    2. Find the expiration date on the outside packaging and do not use reagents past their expiration date.

    3. The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.

  • 组分（Materials Provided）

    ID
    Components
    Size
    RES036-C01
    Pre-coated Anti-4-1BB Ligand Antibody Microplate
    1 plate(8×12 strips)
    RES036-C02
    Human 4-1BB Ligand Standard
    20 μg
    RES036-C03
    Biotin-Anti-4-1BB Ligand Antibody
    20 μg
    RES036-C04
    Streptavidin-HRP
    50 μL
    RES036-C05
    10×Washing Buffer
    50 mL
    RES036-C06
    2×Dilution Buffer
    50 mL
    RES036-C07
    Substrate Solution
    12 mL
    RES036-C08
    Stop Solution
    7 mL

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

数据展示

  • 典型数据-Typical Data

    Please refer to DS document for the assay protocol.

    4-1BB Ligand TYPICAL DATA

    For each experiment, a standard curve needs to be set for each micro-plate, and the specific OD value may vary depending on different laboratories, testers, or equipments. The following example data is for reference only.

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背景介绍

Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

前沿进展

 
药物研发进展
  • 英文全称：

    Tumor necrosis factor ligand superfamily member 9

  • 中文全称：

    肿瘤坏死因子配体超家族成员9

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    2 详情

  • 最高研发阶段：

    临床二期

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