收藏产品 产品信息
抗体来源（Source）
Polyclonal Tbr1 Antibody, Rabbit IgG is a polyclonal antibody purified from rabbit serum.
Gene Synonyms: TBR1, T-box brain transcription factor 1, T-box brain gene 1.
种属（Species）
Rabbit polyclonal antibodies
亚型（Isotype）
Rabbit IgG
抗体类型（Antibody Type）
Polyclonal Antibody
种属反应性（Reactivity）
Mouse, rat, human; Others have not been tested
免疫原（Immunogen）
Mouse TBR1 peptide fused to GST.
特异性（Specificity）
Usually, it is easier to get a positive signal in sections of juvenile animal tissues than that of adults. Immunogen: Mouse TBR1 peptide fused to GST.
应用（Application）
| Application | Recommended Usage |
| IF | 1:200~500 |
纯化（Purification）
Protein A purified / Protein G purified
制剂（Formulation）
Supplied as 0.2 μm filtered solution in pH7.4, PBS, 65 mM Tris, 50 Mm Glycine with 40% glycerol as protectant.
Contact us for customized product form or formulation.
运输（Shipping）
This product is supplied and shipped with blue ice, please inquire the shipping cost.
存储（Storage）
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- Shipped at -20°C. Store at -20°C for 3 years;
- Shipped at -20°C. Store at -80°C for 5 years.
产品数据图
活性（Bioactivity）-Immunostaining
2D cell staining: Immunofluorescent staining (10X) of cerebral organoid-derived neurons (CIPO-BWL001K) labeling Tbr1 (Red) with purified TB1-S457 at 1:200 dilution. DAPI (blue) was used as nuclear counterstain.
Protocol
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背景
The neuron-specific transcription factor T-box brain 1 (Tbr1) is a transcription factor that is highly expressed in glutamatergic early-born cortical neurons, and is specifically expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb. Tbr1 is thought to play an important role in neuronal migration and axonal projection during cortical development. Tbr1-/- mice have been characterized by neonatal lethality, severe defects in the axonal projections of the cerebral cortex and impairment of neuronal migration of the cerebral cortex and amygdala.
Huang TN, et al. Nat Neurosci. 2014;17(2):240-7. doi: 10.1038/nn.3626.
Hevner RF, et al. Neuron. 2001;29(2):353-66. doi: 10.1016/s0896-6273(01)00211-2.
General Notes: FOR RESEARCH USE ONLY.
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