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描述/背景（Background）
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.
种属（Host Species）
Mouse
克隆号（Clone）
2F3
适用方法（Application）
IHC
效价（Property）
1：500
状态（State）
Liquid
阳性对照（Positive Control）
Human Tonsil Tissues
克隆类型（Clonality）
Monoclonal
分子别名（Synonym）
PD1, CD279, PD-1, PDCD1
研究领域（Research Field）
Cancer Drug Targets
抗体来源（Source）
Mouse
同种型（Isotype）
IgG
储存（Storage）
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
质量管理控制体系（QMS）
数据展示
质控样本（Control Sample）
Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelled with HGS-S238 at 1/500 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
肿瘤样本（Cancer Sample）
Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S238 at 1/500 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
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