Canine IL-3 R alpha / CD123 Protein, His Tag

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货号-规格
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ILA-C52H3-100ug
¥3675.00
ILA-C52H3-1mg
¥24255.00
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产品信息

分子别名(Synonym)

IL3R,IL3RA,IL-3Ra,IL-3R-alpha,IL3RAY,IL3RX,IL3RY,CD123 antigen,CD123,hIL3Ra,hIL-3Ra,MGC34174,IL-3 R alpha

表达区间及表达系统(Source)

Canine IL-3 R alpha, His Tag (ILA-C52H3) is expressed from human 293 cells (HEK293). It contains AA Ser 33 - Asp 315 (Accession # XP_038305195.1).

Predicted N-terminus: Ser 33

Request for sequence

蛋白结构(Molecular Characterization)

Online(Ser 33 - Asp 315) XP_038305195.1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 34.9 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.

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电泳(SDS-PAGE)

Canine IL-3 R alpha, His Tag (Cat. No. ILA-C52H3) SDS-PAGE gel

Canine IL-3 R alpha, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

 

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背景

Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor α chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.

 

前沿进展

 
靶点信息
  • 英文全称:

    Interleukin-3 receptor subunit alpha

  • 中文全称:

    白细胞介素-3受体α亚基

  • 种类:

  • 上市药物数量:

    1 详情

  • 临床药物数量:

    36 详情

  • 最高研发阶段:

    批准上市

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