抗CAR Linker抗体
“CAR”是CAR细胞疗法成功的关键所在，也是推动该疗法变革性进展的核心驱动力。为助力CAR细胞疗法的开发，ACROBiosystems百普赛斯倾力打造一系列抗CAR Linker抗体。这些抗体经过精密设计，精准靶向常用的G4S Linker和Whitlow/218 Linker，覆盖PE、APC、Alexa Fluor™等多种荧光标记形式，为CAR分子表征和功能检测提供突破性解决方案。此外，我们推出的 Premium-grade抗CAR Linker抗体 ，通过严苛的质量控制，展现出卓越的性能，广泛适用于细胞激活、分选等关键应用场景。凭借技术创新与高品质保障，ACROBiosystems以领先的解决方案赋能CAR细胞疗法研发，助力科学家加速从基础研究到临床转化的每一步，为细胞疗法的未来注入新动能。
细胞表征
细胞激活
细胞分选
细胞富集
产品列表
| CAR Linker | Cat. No. | Species | Product Description |
|---|---|---|---|
| G4S linker | G4S-PFMY25 | Rabbit | PE-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (0.03% Proclin) |
| G4S linker | G4S-AFMY25 | Rabbit | APC-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (0.03% Proclin) |
| G4S linker | G4S-FAFYP1 | Rabbit | FITC-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (0.03% Proclin) |
| G4S linker | G4S-AEFYP1 | Rabbit | Alexa Fluor™ 555-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (0.03% Proclin) |
| G4S linker | G4S-ABFYP1 coming soon! | Rabbit | Alexa Fluor™ 647-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (0.03% Proclin) |
| G4S linker | G4S-BLM25G0 | Rabbit | Biotinylated Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016), premium grade |
| G4S linker | G4S-CFM25G0 | Rabbit | PE-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016), premium grade |
| G4S linker | G4S-HFM25G0 | Rabbit | APC-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016), premium grade |
产品优势
高亲和力： 基于单B细胞抗体平台开发的兔单克隆抗体。
高特异性： 与外周血单核细胞（PBMCs）无非特异性结合。
种属、亚型通用： 不受单链抗体（scFv）亚型和种属限制，可兼容各种单链抗体。
体内外通用： 不受抗原封闭和血清影响，体内和体外环境均可适用。
PG级产品： 适用于CAR细胞激活、分选及富集。
验证数据
经类CAR细胞批检放行
经流式验证，PE荧光标记兔抗G4S Linker抗体可高特异与Anti-CD19 (G4S)4、Anti-MSLN (G4S)3、Anti-CD22 (G4S)3 等类CAR细胞结合。
Flow cytometric analysis of Anti-CD19 CAR-293/Anti-MSLN CAR-293//Anti-CD2 CAR-293 cells staining with PE-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (Cat. No. G4S-PFMY25) at 1:50 dilution (2 μL of the antibody stock solution corresponds to labeling of 1e6 cells in a final volume of 100 µL), compared with isotype control antibody. PE signal was used to evaluate the binding activity.
极低非特异信号：经PBMC双染验证
Non-specificity of PE-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016), premium grade (Cat. No. G4S-CFM25G0) binding to CD3+ cells present in human PBMC. 5e5 of human PBMCs were simultaneously stained with FITC-labeled anti-CD3 antibody and PE-Labeled Anti-G4S linker Antibody (016) (2 μL of the antibody stock solution corresponds to labeling of 5e5 cells in a final volume of 100 µL) and washed and then analyzed with FACS. Both FITC and PE positive signals was used to evaluate the non-specific binding activity to human CD3+ cells (QC tested).
阳性信号高于竞品
Flow cytometric analysis of Anti-CD19 CAR-293 cells staining with PE-Labeled Monoclonal Anti-G4S linker Antibodies (Cat. No. G4S-PFMY25). PE signal was used to evaluate the binding activity of anti-G4S linker antibody. The biological activity level of ACRO is superior to competitor C.
• Datasheet -PE-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (0.03% Proclin)
• Datasheet -PE-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016), premium grade
- 背景
- 产品列表
- 产品优势
- 验证数据