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产品信息
优势特色（Features）
- Designed under ISO 9001:2015 and ISO 13485:2016
- Manufactured and QC tested under a GMP compliance factory
- Animal-Free materials
- Beta-lactam materials free
- Batch-to-batch consistency
- Stringent quality control tests
表达区间及表达系统（Source）
GMP Human 4-1BB Ligand Protein, Fc Tag (GMP-41LH26) is expressed from human 293 cells (HEK293). It contains AA Arg 71 - Glu 254 (Accession # P41273-1).
Predicted N-terminus: Pro
Request for sequence
蛋白结构（Molecular Characterization）
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 87.5 kDa. The protein migrates as 95 kDa±5 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素（Endotoxin）
Less than 10 EU/mg by the LAL method.
蛋白A残留（Protein A）
<5 ppm of protein tested by ELISA.
宿主蛋白残留（Host Cell Protein）
<0.5 ng/µg of protein tested by ELISA.
宿主核酸残留（Host Cell DNA）
<0.02 ng/μg of protein tested by qPCR.
无菌（Sterility）
The sterility testing was performed by membrane filtration method described in CP<1101>, USP<71> and Eur. Ph. 2.6.1.
支原体（Mycoplasma）
Negative.
纯度（Purity）
>95% as determined by SDS-PAGE.
制剂（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with protectants.
Contact us for customized product form or formulation.
运输（Shipping）
This product is supplied and shipped with blue ice, please inquire the shipping cost.
存储（Storage）
Upon receipt, store it immediately at -20°C or lower for long term storage.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 5 years in lyophilized state;
- -70°C for 12 months under sterile conditions after reconstitution.
产品数据图
电泳（SDS-PAGE）
GMP Human 4-1BB Ligand Protein, Fc Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
活性（Bioactivity）-Bioactivity CELL BASE
GMP Human 4-1BB Ligand Protein, Fc Tag (Cat. No. GMP-41LH26) induce IL‐8 secretion in HT1080 human CD137 cell line. The specific activity of GMP Human 4-1BB Ligand Protein, Fc Tag is＞1.00 x 10^5 U/mg (QC tested).
Protocol
The activity of GMP Human 4-1BB Ligand Protein, Fc Tag (Cat. No. GMP-41LH26) was higher than other competing products.
稳定性（Stability）
The Cell based assay shows that GMP Human 4-1BB Ligand Protein, Fc Tag (Cat. No. GMP-41LH26) is stable at 37°C for 16 hours.
The Cell based assay shows that GMP Human 4-1BB Ligand Protein, Fc Tag (Cat. No. GMP-41LH26) is stable at 4°C for 180 days.
The Cell based assay shows that GMP Human 4-1BB Ligand Protein, Fc Tag (Cat. No. GMP-41LH26) is stable after freezing and thawing 3 times.
The Cell based assay shows batch-to-batch consistency between Acro's GMP and PG 4-1BB Ligand.
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背景
Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
前沿进展
靶点信息 - 英文全称：
Tumor necrosis factor ligand superfamily member 9
- 中文全称：
肿瘤坏死因子配体超家族成员9
- 种类：
- 上市药物数量：
0 详情
- 临床药物数量：
2 详情
- 最高研发阶段：
临床二期
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