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NKG2A

NKG2A信息

英文名称:NK cell lectin-like receptor subfamily C member 1上市药物数量0
中文名称自然杀伤细胞凝集素样受体亚家族C成员1临床药物数量5
靶点别称CD159a，NKG2A，KLRC1，Killer Cell Lectin Like Receptor C1，Killer Cell Lectin-Like Receptor Subfamily C， Member 1，CD159 Antigen-Like Family Member A，NKG2-1/B Activating NK Receptor，NKG2-A/B-Activating NK Receptor，NK Cell Receptor A，NKG2-A/NKG2-B Type II Integral Membrane Protein，NKG2-A/B Type II Integral Membrane Protein，Natural Killer Group Protein 2，Natural Killer Cell Lectin，C-Lectin Type II Protein，CD159a Antigen，NKG2，NKG2-B，NKG2-A最高研发阶段临床三期
英文名称:NK cell lectin-like receptor subfamily C member 1
中文名称自然杀伤细胞凝集素样受体亚家族C成员1
靶点别称CD159a，NKG2A，KLRC1，Killer Cell Lectin Like Receptor C1，Killer Cell Lectin-Like Receptor Subfamily C， Member 1，CD159 Antigen-Like Family Member A，NKG2-1/B Activating NK Receptor，NKG2-A/B-Activating NK Receptor，NK Cell Receptor A，NKG2-A/NKG2-B Type II Integral Membrane Protein，NKG2-A/B Type II Integral Membrane Protein，Natural Killer Group Protein 2，Natural Killer Cell Lectin，C-Lectin Type II Protein，CD159a Antigen，NKG2，NKG2-B，NKG2-A
上市药物数量0
临床药物数量5
最高研发阶段Phase 3 Clinical

NKG2A产品列表

  • 属性

    Protein (4)

  • 产品库

    在线 (4)

  • 物种

    Human (2)Cynomolgus (1)Mouse (1)

  • 标签

    His Tag (3)Fc Tag (1)

  • 标记

    Unconjugated (4)

共 4 项数据
  • 1

NKG2A分子背景

NKG2A/CD159a is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors that inhibits innate immune system activation, also known as KLRC1, CD159a, NK cell receptor A and NKG2-A/NKG2-B type II integral membrane protein. NKG2A marks a unique immune effector subset preferentially co-expressing the tissue-resident CD103 molecule, but not immune checkpoint inhibitors. NKG2A blockade therapy operated through CD8 T cells, but not NK cells. The increase in NKG2A expression might be induced by IL-10, which was present at a high level in the plasma of HCC patients. Blocking IL-10 could specifically inhibit NKG2A expression in NK cells. These findings indicate that NKG2A expression is influenced by factors from cancer nests and contributes to NK cell exhaustion, suggesting that NKG2A blockade has the potential to restore immunity against liver tumors by reversing NK cell exhaustion.

NKG2A分子别名

NKG2A,CD159a,KLRC1,NK cell receptor A

产品评论

  • mi********hotmail.com 2022-06-29
    1人点赞
    Cynomolgus NKG2A / CD159a Protein, His Tag
    我们采购这个蛋白进行小鼠免疫，后期筛选能够结合猴源NKG2A蛋白的鼠源抗体分子。蛋白入库后，我们进行了纯度检测，纯度能够满足免疫要求。
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