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LRRC32

LRRC32信息

英文名称:Transforming growth factor beta activator LRRC32上市药物数量0
中文名称糖蛋白A主导重复序列临床药物数量5
靶点别称Leucine Rich Repeat Containing 32，D11S833E，Garpin，Leucine-Rich Repeat-Containing Protein 32，LRRC32，Transforming Growth Factor Beta Activator LRRC32，GARP，Glycoprotein A Repetitions Predominant最高研发阶段临床三期
英文名称:Transforming growth factor beta activator LRRC32
中文名称糖蛋白A主导重复序列
靶点别称Leucine Rich Repeat Containing 32，D11S833E，Garpin，Leucine-Rich Repeat-Containing Protein 32，LRRC32，Transforming Growth Factor Beta Activator LRRC32，GARP，Glycoprotein A Repetitions Predominant
上市药物数量0
临床药物数量5
最高研发阶段Phase 3 Clinical

LRRC32产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    Fc Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

LRRC32分子背景

Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.

LRRC32分子别名

GARP,Garpin,D11S833E
  • 分子信息
  • 产品列表