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Fc gamma RIIB / CD32b

Fc gamma RIIB / CD32b信息

英文名称:Low affinity immunoglobulin gamma Fc region receptor II-b上市药物数量0
中文名称低亲和力免疫球蛋白γFc区受体II-B临床药物数量5
靶点别称IgG Fc Receptor II-C，Fc Fragment Of IgG， Low Affinity IIb， Receptor (CD32)，Fc Gamma Receptor IIb，IgG Fc Receptor II-B，Fc-Gamma RII-B，FcRII-B，CDw32，FCG2，Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B，Fc Fragment Of IgG， Low Affinity II， Receptor For (CD32)，Fc Gamma RIIb，CD32 Antigen，CD32B，FCGR2，Fc-gamma-RIIb，FCGR2B，IGFR2，CD32，Fc Fragment Of IgG Receptor IIb，Fc-Gamma RII-C，Low Affinity Immunoglobulin Gamma Fc Region Receptor II-C，Fc Fragment Of IgG， Low Affinity IIb， Receptor For (CD32)，FcRII-C，FCGR2C，Fc-Gamma-RIIc最高研发阶段临床三期
英文名称:Low affinity immunoglobulin gamma Fc region receptor II-b
中文名称低亲和力免疫球蛋白γFc区受体II-B
靶点别称IgG Fc Receptor II-C，Fc Fragment Of IgG， Low Affinity IIb， Receptor (CD32)，Fc Gamma Receptor IIb，IgG Fc Receptor II-B，Fc-Gamma RII-B，FcRII-B，CDw32，FCG2，Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B，Fc Fragment Of IgG， Low Affinity II， Receptor For (CD32)，Fc Gamma RIIb，CD32 Antigen，CD32B，FCGR2，Fc-gamma-RIIb，FCGR2B，IGFR2，CD32，Fc Fragment Of IgG Receptor IIb，Fc-Gamma RII-C，Low Affinity Immunoglobulin Gamma Fc Region Receptor II-C，Fc Fragment Of IgG， Low Affinity IIb， Receptor For (CD32)，FcRII-C，FCGR2C，Fc-Gamma-RIIc
上市药物数量0
临床药物数量5
最高研发阶段Phase 3 Clinical

Fc gamma RIIB / CD32b产品列表

  • 属性

    Protein (5)Cell (4)

  • 产品库

    在线 (9)

  • 物种

    Mouse (2)Cynomolgus (2)Human (4)Rat (1)

  • 标签

    His Tag (3)His Tag & Avi Tag (2)

  • 标记

    Unconjugated (3)Biotin-labeled (2)

共 9 项数据
  • 1

Fc gamma RIIB / CD32b分子背景

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.

Fc gamma RIIB / CD32b分子别名

FCGR

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