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DPPIV

DPPIV信息

英文名称:Dipeptidyl peptidase IV上市药物数量36
中文名称二肽基肽酶IV临床药物数量31
靶点别称Dipeptidyl peptidase IV membrane form，T-cell activation antigen CD26，Adenosine deaminase complexing protein 2，Dipeptidyl peptidase IV，Dipeptidyl peptidase IV soluble form，ADCP2，Dipeptidyl peptidase 4，ADCP-2，ADABP，DPP4，Dipeptidylpeptidase IV (CD26， Adenosine Deaminase Complexing Protein 2)，DPP IV，TP103，CD26，Dipeptidyl-Peptidase 4，Dipeptidylpeptidase 4，CD26 Antigen，DPPIV，Xaa-Pro-Dipeptidylaminopeptidase，Gly-Pro Naphthylamidase，Post-Proline Dipeptidyl Aminopeptidase IV最高研发阶段批准上市
英文名称:Dipeptidyl peptidase IV
中文名称二肽基肽酶IV
靶点别称Dipeptidyl peptidase IV membrane form，T-cell activation antigen CD26，Adenosine deaminase complexing protein 2，Dipeptidyl peptidase IV，Dipeptidyl peptidase IV soluble form，ADCP2，Dipeptidyl peptidase 4，ADCP-2，ADABP，DPP4，Dipeptidylpeptidase IV (CD26， Adenosine Deaminase Complexing Protein 2)，DPP IV，TP103，CD26，Dipeptidyl-Peptidase 4，Dipeptidylpeptidase 4，CD26 Antigen，DPPIV，Xaa-Pro-Dipeptidylaminopeptidase，Gly-Pro Naphthylamidase，Post-Proline Dipeptidyl Aminopeptidase IV
上市药物数量36
临床药物数量31
最高研发阶段Approved

DPPIV产品列表

  • 属性

    Protein (8)

  • 产品库

    在线 (8)

  • 物种

    Human (5)Mouse (1)Cynomolgus (1)Canine (1)

  • 标签

    Fc Tag (1)Tag Free (1)His Tag (4)His Tag & Avi Tag (2)

  • 标记

    Unconjugated (6)Biotin-labeled (2)

共 8 项数据
  • 1

DPPIV分子背景

Dipeptidyl peptidase-IV (DPPIV) is also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others. DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.

DPPIV分子别名

DPP4,ADABP,ADCP2,CD26,DPPIV,TP103

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