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Human ACHE / Acetylcholinesterase Protein, His Tag (active enzyme)

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  • 分子别名（Synonym）

    acetylcholinesterase (Yt blood group),Acetylcholinesterase,ACHE,apoptosis-related acetylcholinesterase,ARACHE,EC 3.1.1,EC 3.1.1.7,N-ACHE,Yt blood group,YT

  • 表达区间及表达系统（Source）

    Human ACHE, His Tag (AHE-H52H3) is expressed from human 293 cells (HEK293). It contains AA Glu 32 - Leu 614 (Accession # P22303-1).

    Predicted N-terminus: Glu 32

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    ACHE Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 66.5 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 纯度（Purity）

    >95% as determined by SDS-PAGE.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

数据展示

  • 电泳（SDS-PAGE）

    ACHE SDS-PAGE

    Human ACHE, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • 活性（Bioactivity）

    Measured by its ability to cleave Acetylthiocholine. The specific activity is >500 nmol/min/μg, as measured under the described conditions (QC tested).

    Protocol

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背景介绍

The enzyme acetylcholinesterase, also known as AChE or acetylhydrolase, is the primary cholinesterase in the body. It is a serine hydrolase whose primary function is to catalyzes the breakdown of acetylcholine(ACh) and of some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. Acetylcholine deficit has been found in Alzheimer's disease (AD) ans is associated with cognetive decline. Therefore, AChE has been reported to be a viable therapeutic target for the treatment of AD and other dementias. To this end, acetylcholinesterase inhibitors (AChEIs) are commonly used.

前沿进展

 
药物研发进展
  • 英文全称：

    Acetylcholinesterase

  • 中文全称：

    乙酰胆碱酯酶

  • 种类：

  • 上市药物数量：

    27 详情

  • 临床药物数量：

    26 详情

  • 最高研发阶段：

    批准上市

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